Evidence of PSMA Uptake in Brain Metastases in a Patient with Breast Cancer Her2/Neu Positive

Breast cancer is one of the most common causes of brain metastases resulting in a poor survival. The blood-brain barrier is an obstacle to the delivery of chemotherapeutics to the brain; treatment includes whole brain irradiation, stereotactic radio surgery or neurosurgery with whole brain radiation. The angiogenesis may be associated with metastasis independent of either invasion of normal tissue or intra vacation into normal blood or lymph node. Prostate Specific Membrane Antigen (PSMA) expression is seen in the neovasculature of many types of tumors, such as prostate, renal, lung and recently breast cancer. Positron Emission Tomography (PET) imaging with 68Ga-PSMA is very useful in the diagnosis of recurrent prostate cancer, mainly retrospective studies describe the value of 68Ga-PSMA ligand PET/CT in recurrent prostate cancer and most recently as the ragnostic agent, if required provide therapy with 177Lu-PSMA. These case report suggest that PSMA expression in tumor associated neovasculature may be related to the degree and nature of neoangiogenesis. In addition the present case is the first evidence in which tumor viability is demonstrated in brain metastasis in patients live corroborated by PET-CT with 68Ga-PSMA.